Colchicine Overdose in a Suicidal Attempt

Massive Colchicine Overdose with Recovery

Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly, it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multi-organ failure, whether directly from colchicine toxicity or due to ensuing sepsis. We report an extreme cas...

Alopecia Totalis. following Suicidal Colchicine Overdosage.

Comparison of coping mechanisms used by suicidal attempt patients, and those without suicidal history

Introduction: Care of suicidal attempted patient is a challenging task for all health care providers. Coping mechanisms reduce suicide probability by decreasing severity of stressors. Therefore, we aimed at investigating the coping mechanisms used by suicidal attempted patients referred to hospital. Methods: In this case-control study, cases (n= 50) were selected conveniently among patients r...

Colchicine overdose with coingestion of nonsteroidal antiinflammatory drugs.

Colchicine has a low therapeutic index. Its toxic effects generally occur at doses ≥ 0.5 mg/kg. We present the case of a 39-year-old female with toxicity following ingestion of 0.28 mg/kg. The patient presented to the emergency department (ED) with severe nausea, vomiting, and abdominal pain following an intentional multidrug ingestion that included colchicine, indomethacin, and zopiclone. Desp...

Severe hypertriglyceridemia and colchicine intoxication following suicide attempt

Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient's clinical manifestations included abdominal cramps, vomiting, pancytopenia, hypocholesterolemia, and rhabdomyolysis. Two u...